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Finally, the results of one randomized controlled trial in 601 patients with common forms of retinitis pigmentosa indicated that supplementation with 400 IU/day of synthetic vitamin E (equivalent to 180 mg/day of RRR --tocopherol) modestly but significantly accelerated the loss of retinal function compared to placebo (123)

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Consistently, KD was demonstrated to restrain aging-facilitated coronavirus infection in mice, showing activation of ketogenesis, enriched T cells, reduced NLRP3 inflammasome and decreased pathogenic monocytes in the lungs (Ryu et al., 2021)