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Nle-Ang IV 2 and LVV-hemorphin-7 3 , the latter formed after degradation of -globin, were demonstrated to be strong promoters of memory retention and retrieval in rats ( Figure 1 Excellent reviews on Ang IV and its contribution to cognition are available ( Linear Angiotensin IV Analogues and Incorporation of Unnatural Amino Acids After systematic structure activity studies (SAR) of Ang IV analogues, involving glycine and D-amino acid scans in combination with displacement and incorporation of various alternative amino acid residues it became clear that the N-terminal Val-Tyr-Ile residues of the peptide ligands were important for high affinity to the specific binding site identified ( 2 ) combined with an unsubstituted amino group in the N-terminal seemed optimal

None of the investigated variables were associated with GIP z-scores in the univariate analysis

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