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Patients with pre-existing severe liver disease, including decompensated cirrhosis, were generally excluded from pivotal clinical trials, meaning safety data in this population are limited

After injection (monitoring phase) Immediately: Apply cold compress for 10 to 15 minutes First hour: Monitor for any unusual symptoms beyond the injection site First 24 hours: Repeat cold compress every 2 to 3 hours if a reaction develops First 48 hours: Apply hydrocortisone 1% twice daily if redness or itching persists Day 3 to 7: Switch to warm compress if swelling or lumps remain

The study was funded, in part, by the National Institutes of Health (grants P30 AI036214, R01DK121619 and UM1TR004528) and the James B

Once your body acclimates to a new dose level, many patients notice gradual relief over the following 12 weeks