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D., Criscuolo, M., Ficarra, G., et al

Experimental models include isolated perfused hearts (Langendorff), ex vivo working heart preparations, in vivo echocardiography with metabolic phenotyping, transgenic models affecting carnitine metabolism (OCTN2 knockout, CPT-I variants), and large animal models of myocardial infarction

Tirzepatide showed similar cardiovascular improvements in the SURMOUNT trials, with the added benefit of greater magnitude due to greater weight loss