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A heart attack (myocardial infarction) involves actual cardiac tissue death due to blocked coronary blood flow and presents with crushing chest pain, radiating pain to the jaw or left arm, diaphoresis, nausea, and shortness of breath lasting longer than 5 minutes
Because the placebo arms in all the CVOTs now reflect the background CV risk in the population, the study duration required to obtain the desired number of events can be estimated far more accurately based on power calculations
In the GLP-1 era, the scale may show progress while the physiology is telling a more complicated story
The role of psychological, health-behaviour and medical factors in adolescent headache
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