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HSCs sense and respond to infection or inflammation with myeloid-biased differentiation and epigenetic inflammatory training 10,11,12,13,14,15

Surprisingly, to prevent activated neutrophils from releasing their highly cytotoxic inflammatory mediators into the tissue environment and damaging surrounding tissues along the bloodstream, neutrophils spontaneously undergo apoptosis

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Therefore, we developed chaperone-mediated protein degradation (CHAMP) molecules, which are small heterobifunctional compounds that mediate protein degradation by inducing proximity between a target protein and the HSP90 chaperone complex, resulting in target ubiquitination and degradation mediated by the proteasome