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Hormonal imbalances, including fluctuations in testosterone levels, can disrupt the delicate balance of factors maintaining clear skin, leading to increased sebum production, changes in skin cell turnover, inflammation, and acne development

This is consistent with previous of reports of context-dependent action of coregulators at AR target genes, where they preferentially interact with other components of the AR transcriptional complex to control aspects of cell biology and stages of CaP progression [75, 76]

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In vitro experiments revealed that MC5-R in cardiomyocytes mediates the anti-hypertrophic signaling of -MSH