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These effects were noted in obese mice and beta(3)-adrenergic receptor knock-out mice, suggesting that AOD-9604s actions are not mediated directly through the beta(3)-adrenergic receptor, a known facilitator of lipolysis

These findings demonstrated that the duo of rhodiola and saffron might be a potent remedy for alleviating symptoms of depression and anxiety, although further placebo-controlled trials are necessary to validate the effectiveness (62)

174,175,176 In the UC animal model, the more severe the colon injury was, the lower the abundance of Akkermansia

Western blot, RT-qPCR, CCK-8, and cell cycle assay were applied to evaluate the expression level and proliferation