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7 Excess iron stimulates the formation of reactive oxygen species (ROS) via the Fenton reaction, oxidizing phospholipids in unsaturated fatty acid acyl tails, thereby initiating lipid peroxidation

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The included trials also varied substantially in their populations, treatments and study designs, which may have affected the precision of the estimates

While the FDA definitions of categories 2 and 3 dont state overtly that substances in those categories may not be compounded, they do state that FDA can take regulatory action against pharmacies using those substances