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In addition to direct damage and oxygen-free radical production, the presence of radiation causes microcirculatory dysfunction in bone tissue, leading to increased vascular permeability and vasoconstriction, which in turn leads to the side effect of ischemia and hypoxia in bone tissue 20 While radiotherapy is an effective treatment for cancer, its common side effects, including the previously mentioned radiation inflammation and damage, cannot be overlooked

S., Bryant, P

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For instance, oxidative stress could cause GSH loss though oxidation