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The 2024 identification of lateral septal GLP-1R neurons as the primary locus of liraglutide's anorectic effect rather than the hypothalamic GLP-1R-expressing neurons that constituted the prior working model implies that the satiety benefit depends on a discrete cell population whose adaptive behavior during chronic agonist exposure has not been systematically characterized (Shi et al., 2024)

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Findings establish overweight/obesity as a modifiable risk factor for cardiovascular disease Image content: This image is available to view online

If properly applied, it may inhibit cancer development by mimicking the GS state