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It's happening in your body
It serves as a coenzyme in over 100 enzymatic reactions, most of them involving amino acid metabolism, neurotransmitter synthesis, and glycogen breakdown
Genetic evidence has indicated that ferredoxin 1 (FDX1)-knockout cells were resistant to cuproptosis, confirming that loss of FDX1, a key regulator of copper toxicity signaling, prevents the lipoylated protein aggregation cascade triggered by copper accumulation
As result 2 in contrast to 1 and 3 more effectively stabilizes occluded E1P state relative to the outward-open E2P state of enzyme that leads to the decrease of K + affinity (Hilbers et al., 2016)
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