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(Sound familiar?) Remember when your parents told you to eat your carrots when you were a kid

The role of PPAR in fat metabolism and ketogenic diets

On the other hand, especially during the late stages of disease or under specific microenvironmental signals (e.g., high phosphate, uremic toxins), their excessive activation or phenotypic instability (imbalance in phenotypic plasticity) can transform them into pathogenic factors (63)