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Administration of fibroblast growth factor-21 (FGF21) and analogues and antibodies that exhibit agonism of the fibroblast growth factor receptor 1 (FGFR1)Klotho beta (KLB) receptor complex can reduce body weight, liver fat, insulin resistance and blood glucose in animal models of obesity and diabetes, and initial clinical studies have encouraged further interest [77]

101,107,109 Improving drug delivery across the BBB can be another important direction, other than comparing potency of the various GLP-1 agonists to differentiate within this drug class

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doi: 10.1038/ncomms11932 100 ZhouQLinHWangSWangSRanYLiuYet al