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The peptides short half-life of 4-6 hours means twice-daily dosing produces more consistent tissue levels than single daily administration

Consequently, these cell populations may serve as potential therapeutic targets to limit fibrosis progression

More extensive preclinical and clinical studies, as well as randomized controlled trials, are also required to verify further the beneficial effect of targeting TMAO and its metabolic process, such as prebiotics and probiotics in AF patients

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