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Before the introduction of the concept of ferroptosis in 2012, lipid peroxidation was believed to reduce the fluidity of spermatozoal membranes, affect the quality of spermatozoa, and disrupt membrane fusion during sperm-egg binding [72, 73]

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Judging from the fact that -GCS and GS proteins do not associate and that their gene expression is controlled differently [141], it is reasonable to consider that in certain situations, -GCS acts dominantly compared with GS and produces -glutamyl peptides other than glutathione