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Consistently, by ChIP assay, we detected significant NRF2 binding in Nqo1 and Slc7a11 loci, along with induced association of H3K4Me4 and H3K9Ac after DMF treatment (Fig

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It is the most clinically studied of the three, with topical trials showing collagen, fine-line, and skin-density changes, and a large body of in-vitro work on gene expression and wound healing