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Early ferroptotic intermediates can promote M1 activation, whereas chronic ferroptotic stress and lipid peroxides tend to skew macrophages toward immunosuppressive phenotypes, as shown in Figure 5

all authors reviewed and edited the draft

One explanation for the rarity of successful weight loss maintenance is that an energy deficit and loss of body fat are both associated with increases in appetite and food intake [5, 6]

Farrand AQ, Gregory RA, Scofield MD, Helke KL, Boger HA (2015) Effects of aging on glutamate neurotransmission in the substantia Nigra of Gdnf heterozygous mice