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Provoked (Challenge) Tests: A patient is given a chelator to pull the heavy metals out of where they are stored in the body, so they can be measured.&However, the lab values for these tests are then compared to non-provoked samples

Receptor specificity: The fragment may interact with a distinct receptor or signalling pathway from the primary GH receptor (GHR), which is the subject of ongoing research investigation

Chemosensitivity tests also have less predictive ability in metastatic cancer because cancer that has spread may have a different chemosensitivity profile than the primary tumor

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