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In developmental neurobiology, Arnold proposed three categories of sex differentiation mechanisms: (1) organizational differences driven by fetal hormonal exposure

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Oxyntomodulin, which contains the glucagon sequence with a carboxyterminal extension, is a dual agonist of glucagon and GLP-1 receptors Glicentin, which contains the sequence of oxyntomodulin (and thus also of glucagon) with an N-terminal extension, and its receptor remains unknown Similar to GLP-1, oxyntomodulin and glicentin has an insulinotropic action and exerts an incretin-like effect