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Cheap and widely available, but poorly absorbed

6.2 Modulation of gut microbiota Recent research suggests that GLP-1 receptor agonists significantly affect the composition of gut microbiota, revealing a new mechanism that contributes to metabolic advantages (Liang et al

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Tirzepatide is also less effective at reducing body weight in T2D patients compared to patients without (15.7% weight loss, SURMOUNT-2 and 22.5% weight loss, SURMOUNT-1, respectively)