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Key Differences at a Glance Sermorelin: - First-generation GHRH analog with decades of clinical use - Half-life: 10-20 minutes - Requires daily or twice-daily injection - FDA-approved (for GH deficiency in children, used off-label in adults) - Well-established long-term safety data - Lower cost per vial in many cases - Produces shorter, more natural GH pulses CJC-1295 (Mod GRF 1-29, without DAC): - Modified GHRH analog with improved stability - Half-life: approximately 30 minutes - Can be dosed 1-3 times daily - Not FDA-approved but widely used in clinical practice - Produces stronger GH pulses per injection - Often combined with Ipamorelin for combined effect - More potent per microgram than Sermorelin The fundamental difference is potency and duration

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Curr Opin Cardiol 34(6):687692

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