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For general context, see peer-reviewed articles in major journals (reading list below)

SEC45 and ARG50 have also been previously observed to be able to form interactions with known inhibitors [10, 22, 26]

Health and lifestyle information included smoking status (non-smoker vs current smoker), alcohol consumption as units per week, physical activity assessed using the International Physical Activity Questionnaire (IPAQ, expressed in Metabolic Equivalent Total (MET) minutes per week [46], and body mass index (BMI) measured during physical examination