These mechanistic pathways highlight a distinct advantage of microbiome-based interventions: they operate across multiple pathological domains immune signaling, mitochondrial stability, synaptic plasticity, and epigenetic regulation making them inherently multimodal when compared to traditional single-target drugs [163]
62 reported that ERS was observed in mice 12 h after APAP treatment, and APAP evidently induced liver injury by activating CHOP
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An example is the formation of DON-15-glucuronide (DON-15-GlcA) as the primary human metabolite of DON, which is not observed in most animal species (Maul et al
