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Although further clarification of the structure and mechanism related to the Na + -dependent glutathione transporter is needed, the synthetic skill and expertise in ligand identification, structure modification, and optimization of a medicinal chemist will undoubtedly facilitate the development of more diverse, potent, and effective glutathione transporter-based brain targeting ligands

doi: 10.1074/jbc.M508903200 25 ChenHHanZWangYSuJLinYChengXet al

Iron is required to catalyze some important enzymes in phospholipid peroxidation, such as lipoxygenases (LOX) and cytochrome P450 reductase (POR), as well as many metabolic enzymes involved in intracellular reactive oxygen species (ROS) generation (17)

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