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Steuerman et al conducted a large worldwide survey on the prevalence of cancer in patients with various causes of secondary congenital IGF-1 deficiency and confirmed that subjects with Laron syndrome with congenital IGF-1 deficiency seem protected from the development of cancer [2]

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[3] [4] These medications work through multiple mechanisms: they enhance glucose-dependent insulin secretion, suppress inappropriate glucagon release, and reduce appetite through central nervous system pathways