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Similar results were seen in diabetic rats fed a diet rich in monounsaturated fatty acids from olive oil, where GLP-1 levels increased, weight gain decreased, and insulin sensitivity improved

These consultations allow monitoring of: Glycaemic control through HbA1c measurements (usually every 36 months) Weight changes and body composition Tolerability and adverse effects , particularly gastrointestinal symptoms Blood pressure and heart rate Renal function tests NICE recommends (NG28) that GLP-1 therapy should be continued only if there is demonstrable benefittypically defined as an HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at six months for diabetes indications

The Phase 2 trial protocol uses 4-week intervals between dose increases

This is because the dose of the medication needs to be slowly increased to the full dose over the first 9-16 weeks