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N Engl J Med 2009;360:2503-15.ArticlePubMedPMC 48

Akkermansia muciniphila (1 Billion Total AFU): 10 mg - This is arguably the most research-notable ingredient relative to GLP-1 pathways

According to the medication's SmPC, injection site reactions are among the reported skin-related issues, though they are generally uncommon (may affect up to 1 in 100 people)