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Quick Answer: GLP-1 receptor agonists have not been definitively shown to directly cause clinically significant bone density loss, though the substantial weight reduction they produce may indirectly affect bone metabolism

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The woman lost 50 pounds in nine months and eventually confided that she often took more medication than prescribed when she felt she ate too much. In the journal article, McElroy and her co-authors encouraged doctors to screen for eating disorders and monitor patients weight carefully, noting that patients like the one she described can suffer from atypical anorexia nervosa in which the symptoms of anorexia occur in people whose weight is above normal