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Metabolic syndrome is defined as meeting at least 3 criteria: elevated waist circumference (88 cm for female patients and 102 cm for male patients), triglyceride levels of 150 mg/dL or higher, high-density lipoprotein levels lower than 50 mg/dL for female patients or lower than 40 mg/dL for male patients, systolic blood pressure 130 mm Hg or higher or diastolic blood pressure 85 mm Hg or higher, or fasting plasma glucose levels 100 mg/dL or higher

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It does that largely by prompting the pancreas to release insulin in a measured way, smoothing out the sharp glucose swings that would otherwise follow eating

FDA Analysis Accompanying the initial adverse event reports were endotoxin test results from a third-party laboratory, which FDA found concerning