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Mechanobiology and mechanotherapy of adipose tissue-effect of mechanical force on fat tissue engineering

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" By measuring this shift, we were able to deduce the speed of the winds much like one could deduce the speed of a passing train by the change in the frequency of the train whistle," explains study co-author Vincent Hue, a planetary scientist at the Southwest Research Institute in the US

Under persistent ER stress, the blockage of PERK-mediated global translation leads to the activation of IRE1/XBP1 (x-box binding protein 1) and ATF6 pathways, which in turn promotes the expression of various ER chaperones and ERAD mechanical components to enhance protein folding capacity and degrade irreversibly damaged proteins (Sharma et al., 2021)