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362 Alzheimers type II astrocytes are characterised by (i) increased size of somata, primary processes and swollen endfeet

A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published

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For a non-gut issue like sciatica, injectable administration is the standard for research to ensure sufficient levels of the peptide reach the target tissues and enter circulation