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The most commonly studied neurometabolites are tNAA ( N -Acetyl Aspartate + N -Acetyl Aspartyl Glutamate), tCr (Creatine + Phosphocreatine), tCho (Choline + Phosphocholine + Glycero-phosphocholine), Glx (Glutamate + Glutamine), and mI (Inositol + Glycine)

In adults with growth hormone receptor deficiency, eight weeks of rhIGF-1 therapy significantly increased whole-body protein synthesis, decreased protein oxidation and increased lean body mass while reducing fat mass, demonstrating enhanced muscle anabolism and nutrient utilization in humans

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