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10.1016/j.canlet.2005.11.050 49 IsaacsonR

Transition metals such as iron, copper, and manganese, act as prooxidant agents, although copper is also essential for the antioxidant function of the protein ceruloplasmin, and copper and manganese are constituents of the cytosolic Cu +2 /Zn +2 and the mitochondrial Mn +2 -superoxide-dismutases (SOD, protective against oxidative processes)

Vitamin C Supplements works alongside glutathione for antioxidant defence

The agency cited the importance of maintaining a stable supply chain for sterilized medical products as a factor in reconsidering the earlier regulatory framework