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Description

The cells (10 6 cells/T25 flask in supplemented DMEM) were transfected using calcium phosphate transfection for the cAMP and the competition binding experiments by mixing 10 g hGLP-1R with 120 l TE buffer and 15 l CaCl 2

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Under normoxic conditions (20% oxygen), a typical biphasic response is observed

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Ketones are metabolized inside cells into acetyl-CoA, which enters the Krebs cycle and generates large amounts of ATP [54]

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YesCYP3A4 inhibitors like grapefruit juice, ketoconazole, or clarithromycin reduce hepatic metabolism and can increase oral bioavailability by 24

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