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Enzymes in the bloodstream degrade it within minutes of release, limiting its therapeutic potential

Peroxidase (POD, EC 1.11.1.7) activity was assayed using the guaiacol test where the enzyme activity is calculated as enzyme protein required for the formation of 1 mol tetraguaiacol min 1 (Chance and Maehly Citation1955)

Furthermore, iron species, especially free iron ions, form specific iron-DA complexes and subsequently mediate extensive DA oxidation to produce deleterious DAQs and ROS, leading to proteasome inhibition, dopaminergic neuron vulnerability and degeneration [107]

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