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These processes may help prevent or delay early neurodegeneration but may not reverse or halt disease once protein aggregation and synaptic loss are well underway. Even though the trials enrolled people with early Alzheimers, Edison noted that the disease likely had been developing silently for decades

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Here, we solve the solution NMR structural models of the p53 transactivation domain in complex with the FOXO4 forkhead domain and in complex with FOXO4-DRI