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Staying hydrated and eating smaller meals makes a big difference

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A biodegradable microsphere loaded with N-glycosylated recombinant glial cell-derived neurotrophic factor (GDNF) was injected into the rat striatum by stereotaxic surgery two weeks after a unilateral partial nigrostriatal lesion induced by the neurotoxic oxidopamin (that selectively destroys dopaminergic neurons)

These studies confirm its safety for topical applications