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The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs

Genetic Factors in GLP-1 Tolerance and Digestive Side Effects Individual variations in how your body processes and responds to GLP-1 medications are partly determined by your genetic makeup, particularly genes controlling GLP-1 receptor function, appetite signaling, and gastrointestinal motility

Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, Aissat A, et al

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