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Often, this will mean putting in a feeding tube

This melanin is produced in cells called melanocytes

In pancreatic cancer, DON treatment reduces the levels of hyaluronic acid and collagen, resulting in extensive remodeling of the extracellular matrix (ECM) surrounding the tumor [183]

However, BCG is associated with severe adverse effects, including acute toxicities (dysuria, hematuria, fever, bladder irritation) and delayed toxicities (flu-like symptoms, pneumonia, hepatitis, granulomatous prostatitis) 81