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HO-1 / mice were used to prove that the deletion of HO-1 would aggravate myocardial injury in ischemia/reperfusion, especially related to diabetes

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Glia 57:12511264 Vargas MR, Pehar M, Cassina P et al (2005) Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival

5 We will return to SURPASS-2 in the head-to-head section, because it is one of the few places where a comparison rests on real randomization rather than cross-trial arithmetic