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We've actually been talking a lot already about the gut brain axis

Rodbard HW, Rosenstock J, Canani LH, Deerochanawong C, Gumprecht J, Lindberg SO, et al

Higher doses might work better for some, but they also raise the risk of side effects

Studies using hippocampal tissue obtained from patients with temporal lobe epilepsy and a mouse model of pilocarpine-induced epilepsy have shown that decreased GLP-1R expression in hippocampal microglia correlates with increased cytokine release and astrocyte activation [73]