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Researchers may use surface modification methods to address this shortcoming

J Neuropathol Exp Neurol 62:475485 van Landeghem FK, Stover JF, Bechmann I, Bruck W, Unterberg A, Buhrer C, von Deimling A (2001) Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat

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This gives the kojic acid time to penetrate and work its magic