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Clinical trial data from the STEP and SURMOUNT programs demonstrate that maximum weight loss typically occurs between 60-72 weeks of treatment, with most patients losing 1-2 pounds per week during the active weight loss phase

Because these medications target different systems, they typically do not directly interfere with each other's primary mechanisms of action

Muscle wasting in the context of T2D and obesity represents not only a complication but also a driver of disease progression, contributing to diminished insulin sensitivity, reduced physical capacity and adverse outcomes [3]

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