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Poor sleep disrupts hormonal regulation, increases cortisol, and impairs metabolic function

A longitudinal study published in 2026 found that baseline microbiome composition predicted glycemic response to semaglutide even in the absence of significant changes in microbiome diversity during treatment consistent with the hypothesis that response determinants are partly established before drug initiation (Dinkov & Pendicheva-Duhlenska, 2026)

Now, a study published in the New England Journal of Medicine has suggested semaglutide can improve knee pain in people with obesity and osteoarthritis

doi: 10.1016/j.mrrev.2019.108295 43 SecosanC.BalulescuL.BrasoveanuS.BalintO.PirteaP.DorinG.et al