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[DOI] [PMC free article] [PubMed] [Google Scholar] Stepan AF, Walker DP, Bauman J, Price DA, Baillie TA, Kalgutkar AS, and Aleo MD (2011) Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

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The critical role of N-Acetyl-L-Cysteine (NAC) and Glutathione in combating heavy metal toxicity and the resulting oxidative stress is extensively documented