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GLP-1RAs can reduce GFR by increasing sodium efflux to the macula densa, increasing tubulo-glomerular feedback and vasoconstriction of afferent arterioles, and may also reduce albuminuria by reducing plasma renin activity, reducing renal oxidative stress, and increasing natriuresis 289

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it needs instead to be taken along with a high carbohydrate intake to help push it into the muscle for future exercise sessions

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