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Study appraisal and synthesis methods We assessed the quality of studies using the RoB2 tool recommended by the Cochrane Handbook, the NewcastleOttawa Quality Assessment Scale (NOS), the checklist recommended by Agency for Healthcare Research and Quality (AHRQ), and the quality evaluation tool recommended by the National Institutes of Health (NIH)

We've found that daily administration is common for studies investigating chronic metabolic effects over several weeks

Data were visualized with GraphPad Prism software version 8

Beyond just energy, B12 can also support a more stable mood and may even help with symptoms of depression