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[Abstract] The number of neurons in the vehicle group is significantly decreased compared with the control group, whereas neuron numbers in the CUMS-exposed mice treated with arctiin and Sertraline hydrochloride (SERT) are apparently recovered

Longer-term data and more studies would help reduce my concerns

In subjects with CAD with LDL-C levels well controlled with a statin, the addition of extended release niacin in AIM-HIGH (732) and extended release niacin plus laropiprant (prostaglandin D2 receptor blocker to inhibit flushing) in HPS-2THRIVE (733) failed to reduce cardiovascular outcomes

While not always first-line, its predictable pharmacokinetics support extended treatment protocols when clinically indicated