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Both pharmaceutical giants appear to be making parallel regulatory arguments aimed at limiting compounded versions of their medications by demonstrating to the FDA that these peptide drugs present inherent challenges that pharmacies cannot reliably overcome through traditional compounding processes

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These observations were corroborated by single-cell calcium imaging studies in slices of arcuate nuclei, demonstrating that GLP-1MK-801 inhibits the NMDA-induced intracellular calcium surge relative to GLP-1 alone (Extended Data Fig